Michael J. Rynkiewicz: search on Z-Library

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1

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an α-ketothiazole arginine

Hongfeng Deng, Thomas D. Bannister, Lei Jin, Robert E. Babine, Jesse Quinn, Pamela Nagafuji, Cassandra A. Celatka, Jian Lin, Tsvetelina I. Lazarova, Michael J. Rynkiewicz, Frank Bibbins, Pramod Pandey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 233 KB

english, 2006

2

Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa

Tsvetelina I. Lazarova, Lei Jin, Michael Rynkiewicz, Joan C. Gorga, Frank Bibbins, Harold V. Meyers, Robert Babine, James Strickler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 325 KB

english, 2006

3

Structural Analysis of a Protective Epitope of the Francisella tularensis O -Polysaccharide

Rynkiewicz, Michael J., Lu, Zhaohua, Hui, Julia H., Sharon, Jacqueline, Seaton, Barbara A.

Journal:

Year:

2012

Language:

english

File:

PDF, 3.08 MB

english, 2012

4

Molecular Recognition of the Substrate Diphosphate Group Governs Product Diversity in Trichodiene Synthase Mutants †,‡

Vedula, L. Sangeetha, Rynkiewicz, Michael J., Pyun, Hyung-Jung, Coates, Robert M., Cane, David E., Christianson, David W.

Journal:

Year:

2005

Language:

english

File:

PDF, 1.25 MB

english, 2005

5

Mechanism of Interaction Between Lung Surfactant Protein-D and Influenza A Virus Hemagglutinin

Chong Goh, Boon, Zou, Xueqing, Rynkiewicz, Michael J., Seaton, Barbara A., Schulten, Klaus J.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 38 KB

english, 2012

6

Effect of Two Point Mutations in Lung Surfactant Protein-D on Enhancing its Inhibition Activity Against Influenza a Virus

Goh, Boon Chong, Zou, Xueqing, Rynkiewicz, Michael J., Seaton, Barbara A., Schulten, Klaus

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 37 KB

english, 2013

7

Mechanisms of Interaction Between Lung Collectins and Influenza a Virus Hemagglutinin

Rynkiewicz, Michael J., Luo, Dong, Leymarie, Nancy, Crouch, Erika C., Hartshorn, Kevan L., Head, James F., McCormack, Francis X., van Eijk, Martin, Zaia, Joseph, Seaton, Barbara A.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 47 KB

english, 2011

8

Chemical Rescue by Guanidine Derivatives of an Arginine-Substituted Site-Directed Mutant of Escherichia coli Ornithine Transcarbamylase †

Rynkiewicz, Michael J., Seaton, Barbara A.

Journal:

Year:

1996

Language:

english

File:

PDF, 310 KB

english, 1996

9

Design, Synthesis, and Biological Evaluation of Peptidomimetic Inhibitors of Factor XIa as Novel Anticoagulants

Lin, Jian, Deng, Hongfeng, Jin, Lei, Pandey, Pramod, Quinn, Jesse, Cantin, Susan, Rynkiewicz, Michael J., Gorga, Joan C., Bibbins, Frank, Celatka, Cassandra A., Nagafuji, Pamela, Bannister, Thomas D.,

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 377 KB

english, 2006

10

Molecular Mechanisms of Inhibition of Influenza by Surfactant Protein D Revealed by Large-Scale Molecular Dynamics Simulation

Goh, Boon Chong, Rynkiewicz, Michael J., Cafarella, Tanya R., White, Mitchell R., Hartshorn, Kevan L., Allen, Kimberly, Crouch, Erika C., Calin, Oliviana, Seeberger, Peter H., Schulten, Klaus, Seaton,

Journal:

Year:

2013

Language:

english

File:

PDF, 1.14 MB

english, 2013

11

X-ray Crystal Structures of D100E Trichodiene Synthase and Its Pyrophosphate Complex Reveal the Basis for Terpene Product Diversity †,‡

Rynkiewicz, Michael J., Cane, David E., Christianson, David W.

Journal:

Year:

2002

Language:

english

File:

PDF, 1.15 MB

english, 2002

12

[Advances in Molecular and Cell Biology] Volume 22 || Protein Crystallography in Medicine

Rynkiewicz, Michael J.

Year:

1997

Language:

english

File:

PDF, 3.03 MB

english, 1997

13

Functional and Structural Characterization of Francisella tularensis O -Antigen Antibodies at the Low End of Antigen Reactivity

Lu, Zhaohua, Rynkiewicz, Michael J., Yang, Chiou-Ying, Madico, Guillermo, Perkins, Hillary M., Roche, Marly I., Seaton, Barbara A., Sharon, Jacqueline

Journal:

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

Year:

2014

Language:

english

File:

PDF, 617 KB

english, 2014

14

Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics

Sharon, Jacqueline, Rynkiewicz, Michael J., Lu, Zhaohua, Yang, Chiou-Ying

Journal:

Year:

2014

Language:

english

File:

PDF, 6.43 MB

english, 2014

15

The binding sites of monoclonal antibodies to the nonreducing end of Francisella tularensis O -antigen accommodate mainly the terminal saccharide

Lu, Zhaohua, Rynkiewicz, Michael J., Yang, Chiou-Ying, Madico, Guillermo, Perkins, Hillary M., Wang, Qi, Costello, Catherine E., Zaia, Joseph, Seaton, Barbara A., Sharon, Jacqueline

Journal:

Year:

2013

Language:

english

File:

PDF, 764 KB

english, 2013

16

The arthropod, but not the vertebrate host or its environment, dictates bacterial community composition of fleas and ticks

Hawlena, Hadas, Rynkiewicz, Evelyn, Toh, Evelyn, Alfred, Andrew, Durden, Lance A, Hastriter, Michael W, Nelson, David E, Rong, Ruichen, Munro, Daniel, Dong, Qunfeng, Fuqua, Clay, Clay, Keith

Journal:

The ISME Journal

Year:

2013

Language:

english

File:

PDF, 194 KB

english, 2013

17

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

Rynkiewicz, Michael J., Schott, Veronika, Orzechowski, Marek, Lehman, William, Fischer, Stefan

Journal:

Journal of Muscle Research and Cell Motility

Year:

2015

Language:

english

File:

PDF, 3.20 MB

english, 2015

18

Unraveling the Dual Role of Surfactant Protein a at Atomistic Detail

Goh, Boon Chong, Rynkiewicz, Michael J., McCormack, Francis X., Seaton, Barbara A., Schulten, Klaus

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 63 KB

english, 2015

19

Does Tropomyosin Slide or Roll over F-Actin during Regulatory Transitions?

Rynkiewicz, Michael, Schott, Veronika, Orzechowski, Marek, Fischer, Stefan, Lehman, William

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 39 KB

english, 2016

20

Cardiomyopathy Linked Mutations in Alpha Tropomyosin Influence Blocked State Stability but not Myosin Strong Binding

Farman, Gerrie P., Rynkiewicz, Michael, Orzechowski, Marek, Lehman, William, Moore, Jeffrey

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 72 KB

english, 2016

21

Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Goh, Boon Chong, Wu, Huixing, Rynkiewicz, Michael J., Schulten, Klaus, Seaton, Barbara A., McCormack, Francis X.

Journal:

Year:

2016

Language:

english

File:

PDF, 1.97 MB

english, 2016

22

The propensity for tropomyosin twisting in the presence and absence of F-actin

Rynkiewicz, Michael J., Fischer, Stefan, Lehman, William

Journal:

Archives of Biochemistry and Biophysics

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

23

NIH Public Access

Rynkiewicz, Michael J, Lu, Zhaohua, Hui, Julia H, Sharon, Jacqueline, Barbara, A

Year:

2013

Language:

english

File:

PDF, 1.26 MB

english, 2013

24

Investigating the Phenotype of Cardiomyopathy-Associated Alpha-Tropomyosin E192K Mutation in Patient-Derived Engineered Heart Tissue

Sewanan, Lorenzo R., Park, Jinkyu, Ren, Yongming, Urdaneta, Angela, Rynkiewicz, Michael, Moore, Jeffrey, Lehman, William, Jacoby, Daniel L., Qyang, Yibing, Campbell, Stuart G.

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 43 KB

english, 2017

25

Structure of the Anti-Cancer Compound TR100 Target-Sites on Tpm3.1 Tropomyosin

Rynkiewicz, Michael, Stehn, Justine, Gunning, Peter, Lehman, William

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 38 KB

english, 2017

26

Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop

Rynkiewicz, Michael J., Wu, Huixing, Cafarella, Tanya R., Nikolaidis, Nikolaos M., Head, James F., Seaton, Barbara A., McCormack, Francis X.

Journal:

Year:

2017

Language:

english

File:

PDF, 885 KB

english, 2017

27

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy

Viswanathan, Meera C., Schmidt, William, Rynkiewicz, Michael J., Agarwal, Karuna, Gao, Jian, Katz, Joseph, Lehman, William, Cammarato, Anthony

Journal:

Year:

2017

Language:

english

File:

PDF, 4.56 MB

english, 2017

28

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

Fischer, Stefan, Rynkiewicz, Michael J., Moore, Jeffrey R., Lehman, William

Journal:

Structural Dynamics

Year:

2016

Language:

english

File:

PDF, 3.56 MB

english, 2016

29

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function

Rynkiewicz, Michael J., Prum, Thavanareth, Hollenberg, Stephen, Kiani, Farooq A., Fagnant, Patricia M., Marston, Steven B., Trybus, Kathleen M., Fischer, Stefan, Moore, Jeffrey R., Lehman, William

Journal:

Biophysical Journal

Year:

2017

Language:

english

File:

PDF, 993 KB

english, 2017

30

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments

Farman, Gerrie P., Rynkiewicz, Michael J., Orzechowski, Marek, Lehman, William, Moore, Jeffrey R.

Journal:

Archives of Biochemistry and Biophysics

Year:

2018

Language:

english

File:

PDF, 1.23 MB

english, 2018

31

Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.

van Eijk, Martin, Rynkiewicz, Michael J., Khatri, Kshitij, Leymarie, Nancy, Zaia, Joseph, White, Mitchell R., Hartshorn, Kevan L., Cafarella, Tanya R., Van Die, Irma, Hessing, Martin, Seaton, Barbara

Journal:

Journal of Biological Chemistry

Year:

2018

Language:

english

File:

PDF, 1.73 MB

english, 2018

32

Tropomyosin Translocation on F-Actin Revealed by Molecular Dynamics Simulations

Kiani, Farooq A., Rynkiewicz, Michael J., Fischer, Stefan, Lehman, William

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 49 KB

english, 2018

33

B-Cell Epitopes in GroEL of Francisella tularensis

Lu, Zhaohua, Rynkiewicz, Michael J., Madico, Guillermo, Li, Sheng, Yang, Chiou-Ying, Perkins, Hillary M., Sompuram, Seshi R., Kodela, Vani, Liu, Tong, Morris, Timothy, Wang, Daphne, Roche, Marly I., S

Journal:

Year:

2014

Language:

english

File:

PDF, 2.35 MB

english, 2014

34

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis

Tripathi, Shweta, Wang, Guangshun, White, Mitchell, Rynkiewicz, Michael, Seaton, Barbara, Hartshorn, Kevan, Waldenström, Jonas

Journal:

Year:

2015

Language:

english

File:

PDF, 1.05 MB

english, 2015

35

Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting

Lehman, William, Li, Xiaochuan, Kiani, Farooq A., Moore, Jeffrey R., Campbell, Stuart G., Fischer, Stefan, Rynkiewicz, Michael J.

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 1.85 MB

english, 2018

36

Spontaneous transitions of actin-bound tropomyosin toward blocked and closed states

Kiani, Farooq A., Lehman, William, Fischer, Stefan, Rynkiewicz, Michael J.

Journal:

The Journal of General Physiology

Year:

2018

Language:

english

File:

PDF, 1.24 MB

english, 2018

37

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

Lehman, William, Rynkiewicz, Michael J., Moore, Jeffrey R.

Journal:

Journal of Muscle Research and Cell Motility

Year:

2019

Language:

english

File:

PDF, 2.88 MB

english, 2019

38

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

Patel, Devanshi, Mez, Jesse, Vardarajan, Badri N., Staley, Lyndsay, Chung, Jaeyoon, Zhang, Xiaoling, Farrell, John J., Rynkiewicz, Michael J., Cannon-Albright, Lisa A., Teerlink, Craig C., Stevens, Je

Journal:

JAMA Network Open

Year:

2019

File:

PDF, 1.92 MB

2019

39

Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry

Patel, Devanshi, Mez, Jesse, Vardarajan, Badri N., Staley, Lyndsay, Chung, Jaeyoon, Zhang, Xiaoling, Farrell, John J., Rynkiewicz, Michael J., Cannon-Albright, Lisa A., Teerlink, Craig C., Stevens, Je

Journal:

JAMA Network Open

Year:

2019

Language:

english

File:

PDF, 1.92 MB

english, 2019

40

A New Twist on the Mechanism of Mutation-Induced Tropomyosin Dysfunction

Rynkiewicz, Michael J., Moore, Jeffrey R., Campbell, Stuart G., Lehman, William

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 44 KB

english, 2019

41

Tropomyosin Cable Formation and Its Influence on the Structural Dynamics of Tropomyosin

Kiani, Farooq A., Lehman, William, Fischer, Stefan, Rynkiewicz, Michael J.

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 42 KB

english, 2019

42

A New Twist on the Mechanism of Mutation-Induced Tropomyosin Dysfunction

Rynkiewicz, Michael J., Moore, Jeffrey R., Campbell, Stuart G., Lehman, William

Journal:

Biophysical Journal

Year:

2019

File:

PDF, 44 KB

2019

43

Tropomyosin Cable Formation and Its Influence on the Structural Dynamics of Tropomyosin

Kiani, Farooq A., Lehman, William, Fischer, Stefan, Rynkiewicz, Michael J.

Journal:

Biophysical Journal

Year:

2019

File:

PDF, 42 KB

2019

44

The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time

Lehman, William, Moore, Jeffrey R., Campbell, Stuart G., Rynkiewicz, Michael J.

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 2.62 MB

english, 2019

45

Functional Implications of Dcm End-to-End Bond Mutation in A-Tropomyosin

Ward Racca, Alice, LaFave, Nicholas, Jones, Stephanie, Rynkiewicz, Michael J., Lehman, William, Moore, Jeffrey R.

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 43 KB

english, 2019

46

Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1

Janco, Miro, Rynkiewicz, Michael J., Li, Liang, Hook, Jeff, Eiffe, Eleanor, Ghosh, Anita, Böcking, Till, Lehman, William J., Hardeman, Edna C., Gunning, Peter W.

Journal:

Scientific Reports

Year:

2019

Language:

english

File:

PDF, 2.38 MB

english, 2019

47

Pathogenic Mechanisms of the Cardiomyopathy-Associated Alpha-Tropomyosin Variant E192K as Revealed by Multiscale Modeling and Experiments

Sewanan, Lorenzo R., Park, Jinkyu, Rynkiewicz, Michael J., Hollenberg, Stephen M., Papoutsidakis, Nikolaos, Jacoby, Daniel L., Moore, Jeffrey R., Lehman, William, Qyang, Yibing, Campbell, Stuart G.

Journal:

Biophysical Journal

Year:

2018

File:

PDF, 43 KB

2018

48

The ACTC M305L Hypertrophic Cardiomyopathy Mutation Results in Hypercontractility and Impaired Relaxation of Drosophila Muscles

Viswanathan, Meera C., Schmidt, William, Madan, Aditi, Sullivan, Leah C., Newhard, Christopher S., Rynkiewicz, Michael J., Lehman, William, Swank, Douglas M., Cammarato, Anthony

Journal:

Biophysical Journal

Year:

2018

File:

PDF, 51 KB

2018

49

Cardiomyopathy Mutation at End-End Overlap of Alpha - Tropomyosin Influences Cooperative Activation and Calcium Sensitivity

Sundar, SaiLavanyaa, Rynkiewicz, Michael J., Lehman, William, Moore, Jeffrey R.

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 52 KB

english, 2019

50

Enhanced Antiviral Activity of Human Surfactant Protein D by Site-Specific Engineering of the Carbohydrate Recognition Domain

van Eijk, Martin, Hillaire, Marine L. B., Rimmelzwaan, Guus F., Rynkiewicz, Michael J., White, Mitchell R., Hartshorn, Kevan L., Hessing, Martin, Koolmees, Peter A., Tersteeg, Monique H., van Es, Maar

Journal:

Frontiers in Immunology

Year:

2019

Language:

english

File:

PDF, 2.79 MB

english, 2019